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Johnkennedy, Nnodim
- Hepatocellular Enzyme Activities and Protein Level Following Administration of Vitamins during Chloroquine Induced Hepatoxicity in Wistar Rats
Abstract Views :350 |
PDF Views:68
Authors
Nnodim Johnkennedy
1,
Ujowundu Cosmus Onyekachi
2,
Udujih Hellen Ifeoma
1,
Okorie Hope
1,
Nwobodo Emmanuel Ikechukwu
3,
Nwadike Constance Nnedimma
1
Affiliations
1 Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, NG
2 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, NG
3 ThankGod Medical Laboratories, Ihiala Anambra State, NG
1 Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, NG
2 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, NG
3 ThankGod Medical Laboratories, Ihiala Anambra State, NG
Source
Indian Journal of Innovations and Developments, Vol 1, No 4 (2012), Pagination: 299-302Abstract
Objective The effect of vitamins against chloroquine induced hepatoxicity was studied in wistar rats. Analysis of serum AST, ALT and ALP activities with those of total protein and albumin were carried out. Method: Single oral administration of chloroquine (970mg/kg body weight) caused significant increase in AST, ALT and ALP while protein and albumin concentration were reduced. However, simultaneous treatment of chloroquine with 200mg/kg body weight and 4.3 mg/kg of vitamin C and E respectively were administered for 14days. Results: The levels serum AST, ALT and ALP were significantly decreased following the treatment with vitamin C and E. Conclusion: These observations suggest that administration of high dose of chloroquine can cause increase in serum hepatocellular enzymes activities, which is suggestive of liver necrosis which can be ameliorated to varying degrees by vitamins C and E. Hence, fruits rich in vitamin C and E are highly recommended in liver disorders.Keywords
Hepato-cellular Enzymes, Protein, Chloroquine, HepatoxicityFull Text
References
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- Alterations in some Biochemical Indices of Hepatic Function in Tuberculosis Patients on Antituberclosis Therapy
Abstract Views :553 |
PDF Views:279
Authors
Nnodim Johnkennedy
1,
Afolabi Emmanuel Abiodun
1,
Udujih Hellen Ifeoma
1,
Okorie Hope
1,
Nwobodo Emmanuel Ikechukwu
2,
Nwadike Constance Nnedimma
1
Affiliations
1 Department of medical laboratory science, faculty of health science, Imo State University Owerri, Imo State, NG
2 Thank god medical Laboratories Ihiala, Anambra State, NG
1 Department of medical laboratory science, faculty of health science, Imo State University Owerri, Imo State, NG
2 Thank god medical Laboratories Ihiala, Anambra State, NG
Source
Indian Journal of Medicine and Healthcare, Vol 1, No 1 (2012), Pagination: 12-15Abstract
This study was to investigate the hepatic pathophysiology and biochemical changes during antituberclosis therapy. Among the intake 200 patients: 60 were on therapy, another 60 were not on therapy, while 80 were non tuberculosis patient. A comparative decrease in the level of total protein and albumin in tuberculosis patients were recorded while increase in Asparate Aminotransfarace (AST), Alanine Aminotransferace (ALT), and Alkaline Phosphatase (ALP) were observed in comparison with the control. On treatment with antituberclosis therapy, the hepatic involvements are transient.Keywords
Biochemical Indices, Hepatic Pathophysiology, Antituberculosis TherapyFull Text
References
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- Alteration of Leptin and C-Peptide Status in Homozygous Sickle Cell Anaemia
Abstract Views :300 |
PDF Views:132
Authors
Nnodim Johnkennedy
1,
C. Meludu Samuel
2,
C. E. Dioka
3,
Martin Ifeanyichukwu
4,
Okorie Hope
1,
G. C. Uloneme
5
Affiliations
1 Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, NG
2 Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001 Nnewi, Anambra State, NG
3 Department of Chemicalpathology, College of Medicine and Health Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, NG
4 Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, NG
5 Department of Human Anatomy, Imo State University, Owerri, Imo State, NG
1 Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, NG
2 Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001 Nnewi, Anambra State, NG
3 Department of Chemicalpathology, College of Medicine and Health Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, NG
4 Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, NG
5 Department of Human Anatomy, Imo State University, Owerri, Imo State, NG
Source
SMU Medical Journal, Vol 3, No 1 (2016), Pagination: 556-564Abstract
The study was carried out to determine the level of leptin and C-peptide in sickle cell anemia. Thirty confirmed sickle cell patients in steady state(HbSS-SS) and thirty normal haemoglobin (HbAA) as well as sixteen sickle cell disease in crises(HbSS-cr) between the ages of 15 to 30 years were selected in this study. Leptin and C-peptide were measured by commercially available ELISA kits. The results obtained showed that the levels of leptin and C-peptide in Sickle cell anaemia patients were significantly elevated when compared with HbAA subjects (P<0.05). However, the level of leptin and C-peptide in sickle cell steady state were highly significant when compared with those in crisis(P<0.05). This may probably implies that leptin and C-peptide decrease could enhance sickle cell crisis. Also, it could provide the understanding of the possible role of leptin and C-peptide in the pathophysiology of sickle cell anaemia.Keywords
Leptin, C-Peptide , Sickle Cell Anaemia, Pathophysiology.Full Text